BRD-K35004659_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K35004659_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CFH complement factor H
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL4 dihydropyrimidinase-like 4
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FAM162A family with sequence similarity 162, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS3 protease, serine, 3
REG1A regenerating islet-derived 1 alpha
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
SDC4 syndecan 4
SFN stratifin
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TMEM176A transmembrane protein 176A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TNS1 tensin 1
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WIF1 WNT inhibitory factor 1
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CENPA centromere protein A
CKAP4 cytoskeleton-associated protein 4
COL3A1 collagen, type III, alpha 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXM1 forkhead box M1
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
PBK PDZ binding kinase
PLXNC1 plexin C1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2S ubiquitin-conjugating enzyme E2S
VRK2 vaccinia related kinase 2