BRD-K35133769_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K35133769_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
C1ORF116 chromosome 1 open reading frame 116
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CTSZ cathepsin Z
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND1B DENN/MADD domain containing 1B
DSE dermatan sulfate epimerase
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GAREM GRB2 associated, regulator of MAPK1
GCG glucagon
HAPLN1 hyaluronan and proteoglycan link protein 1
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA1462 KIAA1462
KRT20 keratin 20, type I
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPRD protein tyrosine phosphatase, receptor type, D
PXDN peroxidasin
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS17 regulator of G-protein signaling 17
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SATB1 SATB homeobox 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPC surfactant protein C
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOCS2 suppressor of cytokine signaling 2
SOX11 SRY (sex determining region Y)-box 11
SPAG16 sperm associated antigen 16
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
TMEM100 transmembrane protein 100
TMEM30B transmembrane protein 30B
TOX thymocyte selection-associated high mobility group box
TSPAN12 tetraspanin 12
TUSC3 tumor suppressor candidate 3
UGDH UDP-glucose 6-dehydrogenase
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHPT1 choline phosphotransferase 1
CRELD2 cysteine-rich with EGF-like domains 2
CST3 cystatin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EGR3 early growth response 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GSTM3 glutathione S-transferase mu 3 (brain)
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
JARID2 jumonji, AT rich interactive domain 2
KDM3A lysine (K)-specific demethylase 3A
KRT13 keratin 13, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC16A leucine rich repeat containing 16A
MSX1 msh homeobox 1
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PLAC8 placenta-specific 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100P S100 calcium binding protein P
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SORD sorbitol dehydrogenase
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIP6 thyroid hormone receptor interactor 6
ZBTB18 zinc finger and BTB domain containing 18
Funding