BRD-K35424586_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K35424586_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ANGPTL2 angiopoietin-like 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
C1QA complement component 1, q subcomponent, A chain
CALD1 caldesmon 1
CCND2 cyclin D2
CES1 carboxylesterase 1
CRABP2 cellular retinoic acid binding protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP5 dual specificity phosphatase 5
FADS1 fatty acid desaturase 1
FLNA filamin A, alpha
FOXO4 forkhead box O4
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
IER3 immediate early response 3
ISLR immunoglobulin superfamily containing leucine-rich repeat
MAPT microtubule-associated protein tau
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MMP11 matrix metallopeptidase 11
MXRA5 matrix-remodelling associated 5
PALLD palladin, cytoskeletal associated protein
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PSIP1 PC4 and SFRS1 interacting protein 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SESN1 sestrin 1
SFN stratifin
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SSPN sarcospan
STEAP1 six transmembrane epithelial antigen of the prostate 1
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
VNN1 vanin 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
CD200 CD200 molecule
COL2A1 collagen, type II, alpha 1
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FGF13 fibroblast growth factor 13
FOXG1 forkhead box G1
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KRT13 keratin 13, type I
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MMP7 matrix metallopeptidase 7
NPY1R neuropeptide Y receptor Y1
PUF60 poly-U binding splicing factor 60KDa
RANBP2 RAN binding protein 2
S100A8 S100 calcium binding protein A8
SMNDC1 survival motor neuron domain containing 1
SP3 Sp3 transcription factor
SST somatostatin
TLE4 transducin-like enhancer of split 4
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
Funding