BRD-K35424586_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-K35424586_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BLVRA biliverdin reductase A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERS6 ceramide synthase 6
DDIT4 DNA-damage-inducible transcript 4
ELOVL6 ELOVL fatty acid elongase 6
EMP1 epithelial membrane protein 1
FBLN5 fibulin 5
FHL1 four and a half LIM domains 1
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
IL1R1 interleukin 1 receptor, type I
LGALS1 lectin, galactoside-binding, soluble, 1
MBD2 methyl-CpG binding domain protein 2
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSL1 male-specific lethal 1 homolog (Drosophila)
NFIB nuclear factor I/B
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPS11 ribosomal protein S11
SOX9 SRY (sex determining region Y)-box 9
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
CASP3 caspase 3, apoptosis-related cysteine peptidase
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CXCL13 chemokine (C-X-C motif) ligand 13
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
MEIS2 Meis homeobox 2
ORC1 origin recognition complex, subunit 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX7 sorting nexin 7
Funding