BRD-K35638681_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K35638681_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA6 annexin A6
AREG amphiregulin
ARHGAP32 Rho GTPase activating protein 32
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
DAD1 defender against cell death 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
KRT19 keratin 19, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOX lysyl oxidase
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MLPH melanophilin
MTMR11 myotubularin related protein 11
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA3 protein disulfide isomerase family A, member 3
PERP PERP, TP53 apoptosis effector
PLAC8 placenta-specific 8
PNRC1 proline-rich nuclear receptor coactivator 1
PRR15L proline rich 15-like
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF3 trefoil factor 3 (intestinal)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACLY ATP citrate lyase
ARPC5L actin related protein 2/3 complex, subunit 5-like
BLCAP bladder cancer associated protein
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CD81 CD81 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GYG1 glycogenin 1
HBEGF heparin-binding EGF-like growth factor
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
JMJD6 jumonji domain containing 6
MICALL1 MICAL-like 1
MREG melanoregulin
MSH6 mutS homolog 6
MTCL1 microtubule crosslinking factor 1
MXRA7 matrix-remodelling associated 7
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
RGS4 regulator of G-protein signaling 4
SLBP stem-loop binding protein
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
TMEM147 transmembrane protein 147
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
ZYX zyxin
Funding