BRD-K35708212_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K35708212_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BRD2 bromodomain containing 2
CCNL1 cyclin L1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CKS2 CDC28 protein kinase regulatory subunit 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
FAM60A family with sequence similarity 60, member A
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLS glutaminase
GMFB glia maturation factor, beta
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
IER2 immediate early response 2
IER3 immediate early response 3
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
OGFRL1 opioid growth factor receptor-like 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RSRC2 arginine/serine-rich coiled-coil 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPAG9 sperm associated antigen 9
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CCNF cyclin F
CFB complement factor B
CHL1 cell adhesion molecule L1-like
COL6A1 collagen, type VI, alpha 1
CRISP3 cysteine-rich secretory protein 3
DEFB1 defensin, beta 1
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
FANCF Fanconi anemia, complementation group F
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
GPM6B glycoprotein M6B
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
NRCAM neuronal cell adhesion molecule
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SRGN serglycin
THAP11 THAP domain containing 11
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)