BRD-K35960502_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K35960502_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EMX2 empty spiracles homeobox 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GTPBP2 GTP binding protein 2
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUND jun D proto-oncogene
LARP6 La ribonucleoprotein domain family, member 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAWR PRKC, apoptosis, WT1, regulator
PDGFA platelet-derived growth factor alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RGS13 regulator of G-protein signaling 13
RNMT RNA (guanine-7-) methyltransferase
SAMD4A sterile alpha motif domain containing 4A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WISP2 WNT1 inducible signaling pathway protein 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASPH aspartate beta-hydroxylase
BAG3 BCL2-associated athanogene 3
CBR1 carbonyl reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP4 dual specificity phosphatase 4
H2AFX H2A histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HMGA2 high mobility group AT-hook 2
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
MSH6 mutS homolog 6
NRP1 neuropilin 1
PON2 paraoxonase 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TBC1D16 TBC1 domain family, member 16
TMEM2 transmembrane protein 2
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S