BRD-K35960502_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K35960502_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL4 acyl-CoA synthetase long-chain family member 4
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EVI2A ecotropic viral integration site 2A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHBA inhibin, beta A
INHBE inhibin, beta E
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NREP neuronal regeneration related protein
PDGFA platelet-derived growth factor alpha polypeptide
PER1 period circadian clock 1
PLK2 polo-like kinase 2
RYBP RING1 and YY1 binding protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
TF transferrin
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TSC22D1 TSC22 domain family, member 1
UBQLN2 ubiquilin 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AHNAK2 AHNAK nucleoprotein 2
CPA3 carboxypeptidase A3 (mast cell)
DPP4 dipeptidyl-peptidase 4
GOLGA8B golgin A8 family, member B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MMP9 matrix metallopeptidase 9
NDNF neuron-derived neurotrophic factor
NPDC1 neural proliferation, differentiation and control, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZK1 PDZ domain containing 1
REEP1 receptor accessory protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX11 SRY (sex determining region Y)-box 11
Funding