BRD-K35960502_NICLOSAMIDE_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K35960502_NICLOSAMIDE_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACKR3 atypical chemokine receptor 3
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL3 B-cell CLL/lymphoma 3
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA4 carbonic anhydrase IV
CAV2 caveolin 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DYNLT1 dynein, light chain, Tctex-type 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MEST mesoderm specific transcript
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYO1D myosin ID
NEB nebulin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OSBPL10 oxysterol binding protein-like 10
OSER1 oxidative stress responsive serine-rich 1
PDE4B phosphodiesterase 4B, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PLVAP plasmalemma vesicle associated protein
PPARG peroxisome proliferator-activated receptor gamma
PXN paxillin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
SEC14L1 SEC14-like 1 (S. cerevisiae)
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TLK2 tousled-like kinase 2
TMCC1 transmembrane and coiled-coil domain family 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZBED2 zinc finger, BED-type containing 2
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C2CD5 C2 calcium-dependent domain containing 5
CCNF cyclin F
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COG2 component of oligomeric golgi complex 2
CORO1A coronin, actin binding protein, 1A
CTSG cathepsin G
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEFB1 defensin, beta 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYNLL1 dynein, light chain, LC8-type 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EIF4A3 eukaryotic translation initiation factor 4A3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAL histidine ammonia-lyase
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1L hematological and neurological expressed 1-like
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IRX5 iroquois homeobox 5
METRN meteorin, glial cell differentiation regulator
MLEC malectin
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PGBD5 piggyBac transposable element derived 5
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RPA3 replication protein A3, 14kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TMEM14A transmembrane protein 14A
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
Funding