BRD-K36007650_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K36007650_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EAF2 ELL associated factor 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI2 peptidyl arginine deiminase, type II
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
TES testin LIM domain protein
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
B3GNT1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CHRDL1 chordin-like 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP4 dual specificity phosphatase 4
FAM57A family with sequence similarity 57, member A
GPX3 glutathione peroxidase 3
HMGN3 high mobility group nucleosomal binding domain 3
HOXA10 homeobox A10
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LBR lamin B receptor
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NMU neuromedin U
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
S100A7 S100 calcium binding protein A7
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TGM2 transglutaminase 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UPK1B uroplakin 1B
WNT5A wingless-type MMTV integration site family, member 5A