BRD-K36038115_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K36038115_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ARL4C ADP-ribosylation factor-like 4C
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DCN decorin
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN1 endothelin 1
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GSDMB gasdermin B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
NVL nuclear VCP-like
PADI2 peptidyl arginine deiminase, type II
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PTN pleiotrophin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
TANK TRAF family member-associated NFKB activator
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL9 chemokine (C-X-C motif) ligand 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FLNB filamin B, beta
FSTL1 follistatin-like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2BD histone cluster 1, H2bd
KLF2 Kruppel-like factor 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MOCOS molybdenum cofactor sulfurase
MSMB microseminoprotein, beta-
PBK PDZ binding kinase
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SORD sorbitol dehydrogenase
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
XPO7 exportin 7