BRD-K36055864_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K36055864_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CDK7 cyclin-dependent kinase 7
CEP57 centrosomal protein 57kDa
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
ICAM1 intercellular adhesion molecule 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PICALM phosphatidylinositol binding clathrin assembly protein
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRAME preferentially expressed antigen in melanoma
RGS2 regulator of G-protein signaling 2
RSL1D1 ribosomal L1 domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SOX11 SRY (sex determining region Y)-box 11
STAT1 signal transducer and activator of transcription 1, 91kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
B3GNT1
BAG3 BCL2-associated athanogene 3
BTN3A2 butyrophilin, subfamily 3, member A2
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG1 cyclin G1
CDC25B cell division cycle 25B
COMMD3 COMM domain containing 3
COPS7A COP9 signalosome subunit 7A
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DYNLL1 dynein, light chain, LC8-type 1
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV5 ets variant 5
FAM102A family with sequence similarity 102, member A
FSTL1 follistatin-like 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KAZN kazrin, periplakin interacting protein
KEAP1 kelch-like ECH-associated protein 1
LBR lamin B receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MEGF9 multiple EGF-like-domains 9
METTL9 methyltransferase like 9
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NDRG3 NDRG family member 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
PAM peptidylglycine alpha-amidating monooxygenase
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PODXL podocalyxin-like
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPRT quinolinate phosphoribosyltransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS11 ribosomal protein S11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TMEM14A transmembrane protein 14A
TXN thioredoxin
TYMS thymidylate synthetase
VGLL4 vestigial-like family member 4
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding