BRD-K36055864_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-K36055864_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ANXA3 annexin A3
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATG12 autophagy related 12
BCL10 B-cell CLL/lymphoma 10
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
CAB39 calcium binding protein 39
CCNL1 cyclin L1
CD1E CD1e molecule
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CTGF connective tissue growth factor
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST1H4J histone cluster 1, H4j
HIST2H2BE histone cluster 2, H2be
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INTS6 integrator complex subunit 6
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
KIF2C kinesin family member 2C
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
OASL 2'-5'-oligoadenylate synthetase-like
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKN2 protein kinase N2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARA retinoic acid receptor, alpha
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBM39 RNA binding motif protein 39
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERTAD2 SERTA domain containing 2
SH3BP4 SH3-domain binding protein 4
SMAD3 SMAD family member 3
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SWAP70 SWAP switching B-cell complex 70kDa subunit
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
USP15 ubiquitin specific peptidase 15
WSB1 WD repeat and SOCS box containing 1
YTHDC1 YTH domain containing 1
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP1 A kinase (PRKA) anchor protein 1
B3GNT1
BCAP31 B-cell receptor-associated protein 31
C14ORF132 chromosome 14 open reading frame 132
C3 complement component 3
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COMT catechol-O-methyltransferase
CSK c-src tyrosine kinase
CXCR4 chemokine (C-X-C motif) receptor 4
DPYSL2 dihydropyrimidinase-like 2
EFCAB14 EF-hand calcium binding domain 14
FAM189B family with sequence similarity 189, member B
FAM57A family with sequence similarity 57, member A
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
HMGN4 high mobility group nucleosomal binding domain 4
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGL immunoglobulin lambda locus
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL32 interleukin 32
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MME membrane metallo-endopeptidase
MPZL1 myelin protein zero-like 1
MT1M metallothionein 1M
MTMR4 myotubularin related protein 4
MUC16 mucin 16, cell surface associated
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIR pirin (iron-binding nuclear protein)
PKM pyruvate kinase, muscle
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PRUNE2 prune homolog 2 (Drosophila)
PUS7 pseudouridylate synthase 7 (putative)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THAP11 THAP domain containing 11
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRAK2 trafficking protein, kinesin binding 2
TRIM29 tripartite motif containing 29
UBE3C ubiquitin protein ligase E3C
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZNF423 zinc finger protein 423
Funding