BRD-K36198571_WAY 170523_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K36198571_WAY 170523_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG1 adhesion G protein-coupled receptor G1
ADM adrenomedullin
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ARG1 arginase 1
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BEX4 brain expressed, X-linked 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CHMP2B charged multivesicular body protein 2B
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
EGFR epidermal growth factor receptor
ENO2 enolase 2 (gamma, neuronal)
F11R F11 receptor
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FAM162A family with sequence similarity 162, member A
FGB fibrinogen beta chain
FZD1 frizzled class receptor 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
ISYNA1 inositol-3-phosphate synthase 1
KDM5D lysine (K)-specific demethylase 5D
KLF11 Kruppel-like factor 11
LINC00341 long intergenic non-protein coding RNA 341
LOX lysyl oxidase
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKL phosphofructokinase, liver
PGK1 phosphoglycerate kinase 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPS4Y1 ribosomal protein S4, Y-linked 1
SARS seryl-tRNA synthetase
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPAG4 sperm associated antigen 4
SST somatostatin
STC2 stanniocalcin 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
BAG2 BCL2-associated athanogene 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
BZW2 basic leucine zipper and W2 domains 2
CBR3 carbonyl reductase 3
CDC25A cell division cycle 25A
CHL1 cell adhesion molecule L1-like
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
DCK deoxycytidine kinase
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPN2 epsin 2
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MCM3 minichromosome maintenance complex component 3
MDFIC MyoD family inhibitor domain containing
MSRB2 methionine sulfoxide reductase B2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP56 NOP56 ribonucleoprotein
PARP2 poly (ADP-ribose) polymerase 2
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMC3IP PSMC3 interacting protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC2 replication factor C (activator 1) 2, 40kDa
S100A2 S100 calcium binding protein A2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC1A structural maintenance of chromosomes 1A
SPRR3 small proline-rich protein 3
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNM synemin, intermediate filament protein
TARBP1 TAR (HIV-1) RNA binding protein 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
Funding