BRD-K36354764_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K36354764_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
FTH1 ferritin, heavy polypeptide 1
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP6 insulin-like growth factor binding protein 6
ISLR immunoglobulin superfamily containing leucine-rich repeat
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF14 kinesin family member 14
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL3 oxysterol binding protein-like 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
CCNA2 cyclin A2
CCND1 cyclin D1
CHGB chromogranin B
CRISP3 cysteine-rich secretory protein 3
CYTL1 cytokine-like 1
DPYSL3 dihydropyrimidinase-like 3
ESR1 estrogen receptor 1
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H4C histone cluster 1, H4c
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT7 keratin 7, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PEG10 paternally expressed 10
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C