BRD-K36363294_I-BET151_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K36363294_I-BET151_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCDC92 coiled-coil domain containing 92
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ETV5 ets variant 5
EZR ezrin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GPR137B G protein-coupled receptor 137B
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
JUND jun D proto-oncogene
KIF2C kinesin family member 2C
KLF2 Kruppel-like factor 2
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCAM melanoma cell adhesion molecule
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NCALD neurocalcin delta
NFIB nuclear factor I/B
NMT2 N-myristoyltransferase 2
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALLD palladin, cytoskeletal associated protein
PECR peroxisomal trans-2-enoyl-CoA reductase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOQ ras homolog family member Q
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
STAT1 signal transducer and activator of transcription 1, 91kDa
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM2 transmembrane protein 2
TMEM50A transmembrane protein 50A
TRPS1 trichorhinophalangeal syndrome I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C5 complement component 5
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC86 coiled-coil domain containing 86
CD1E CD1e molecule
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EVI2A ecotropic viral integration site 2A
FABP1 fatty acid binding protein 1, liver
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FGFBP1 fibroblast growth factor binding protein 1
FST follistatin
GPC3 glypican 3
GPR88 G protein-coupled receptor 88
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPB1 heat shock 27kDa protein 1
ICAM3 intercellular adhesion molecule 3
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
IPO13 importin 13
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAPK13 mitogen-activated protein kinase 13
MARC1 mitochondrial amidoxime reducing component 1
MTA1 metastasis associated 1
MYO10 myosin X
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PCOLCE procollagen C-endopeptidase enhancer
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
RAP1GAP RAP1 GTPase activating protein
RHOBTB3 Rho-related BTB domain containing 3
RXRA retinoid X receptor, alpha
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS3 sorbin and SH3 domain containing 3
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPRR1B small proline-rich protein 1B
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TF transferrin
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)
Funding