BRD-K36363294_I-BET151_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K36363294_I-BET151_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
ALDOC aldolase C, fructose-bisphosphate
ANXA5 annexin A5
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPTF bromodomain PHD finger transcription factor
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
COLEC12 collectin sub-family member 12
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
EDNRA endothelin receptor type A
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FSTL1 follistatin-like 1
FUCA1 fucosidase, alpha-L- 1, tissue
GATA3 GATA binding protein 3
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
KCTD12 potassium channel tetramerization domain containing 12
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LRP4 low density lipoprotein receptor-related protein 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCKSL1 MARCKS-like 1
MEAF6 MYST/Esa1-associated factor 6
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
PALLD palladin, cytoskeletal associated protein
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCYOX1 prenylcysteine oxidase 1
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PHACTR2 phosphatase and actin regulator 2
PLK2 polo-like kinase 2
PNKP polynucleotide kinase 3'-phosphatase
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTCH1 patched 1
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RRAGC Ras-related GTP binding C
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERINC3 serine incorporator 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT3 sirtuin 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
STXBP1 syntaxin binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM100 transmembrane protein 100
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOMM34 translocase of outer mitochondrial membrane 34
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TTC3 tetratricopeptide repeat domain 3
TXNRD1 thioredoxin reductase 1
VCL vinculin
VIM vimentin
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
ARG1 arginase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BCL2A1 BCL2-related protein A1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C1R complement component 1, r subcomponent
CAPN1 calpain 1, (mu/I) large subunit
CCL19 chemokine (C-C motif) ligand 19
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
DDR1 discoidin domain receptor tyrosine kinase 1
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FANCI Fanconi anemia, complementation group I
FHL2 four and a half LIM domains 2
FOXM1 forkhead box M1
GRWD1 glutamate-rich WD repeat containing 1
GYPC glycophorin C (Gerbich blood group)
HMGB2 high mobility group box 2
HOXC10 homeobox C10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM3 intercellular adhesion molecule 3
IER3 immediate early response 3
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KRT18 keratin 18, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MREG melanoregulin
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC1 myosin binding protein C, slow type
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PYCR1 pyrroline-5-carboxylate reductase 1
RAB25 RAB25, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RFC3 replication factor C (activator 1) 3, 38kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX10 sorting nexin 10
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TDO2 tryptophan 2,3-dioxygenase
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
VDAC1 voltage-dependent anion channel 1
Funding