BRD-K36740062_GSK-1070916_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K36740062_GSK-1070916_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
COL16A1 collagen, type XVI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DDB2 damage-specific DNA binding protein 2, 48kDa
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FBN2 fibrillin 2
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HRSP12 heat-responsive protein 12
IGF1R insulin-like growth factor 1 receptor
MVP major vault protein
PTGDS prostaglandin D2 synthase 21kDa (brain)
REG1A regenerating islet-derived 1 alpha
RPS27L ribosomal protein S27-like
S100A8 S100 calcium binding protein A8
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SESN1 sestrin 1
STC1 stanniocalcin 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM22 tripartite motif containing 22
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ADM adrenomedullin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BRCA1 breast cancer 1, early onset
CADM1 cell adhesion molecule 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNE2 cyclin E2
CCR2 chemokine (C-C motif) receptor 2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRZB frizzled-related protein
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
MCM6 minichromosome maintenance complex component 6
MMD monocyte to macrophage differentiation-associated
NELL2 NEL-like 2 (chicken)
NRCAM neuronal cell adhesion molecule
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RNASE4 ribonuclease, RNase A family, 4
RRM2 ribonucleotide reductase M2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TF transferrin
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
ZFP36L2 ZFP36 ring finger protein-like 2
Funding