BRD-K36740062_GSK-1070916_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K36740062_GSK-1070916_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACO2 aconitase 2, mitochondrial
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDOC aldolase C, fructose-bisphosphate
ASS1 argininosuccinate synthase 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BLNK B-cell linker
C14ORF1 chromosome 14 open reading frame 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DFNA5 deafness, autosomal dominant 5
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM50A family with sequence similarity 50, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GCLC glutamate-cysteine ligase, catalytic subunit
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX1 glutathione peroxidase 1
GRN granulin
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2R insulin-like growth factor 2 receptor
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLCB4 phospholipase C, beta 4
PPL periplakin
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM7SF2 transmembrane 7 superfamily member 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM22 tripartite motif containing 22
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL8 chemokine (C-X-C motif) ligand 8
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HJURP Holliday junction recognition protein
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MT1M metallothionein 1M
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51 RAD51 recombinase
RBP1 retinol binding protein 1, cellular
RDX radixin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF6 serine/arginine-rich splicing factor 6
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN transgelin
TAGLN2 transgelin 2
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TPRKB TP53RK binding protein
TPX2 TPX2, microtubule-associated
TRBC1 T cell receptor beta constant 1
TREM1 triggering receptor expressed on myeloid cells 1
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein
Funding