BRD-K36740062_GSK-1070916_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-K36740062_GSK-1070916_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACLY ATP citrate lyase
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
BIRC3 baculoviral IAP repeat containing 3
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLGN calmegin
CLIC4 chloride intracellular channel 4
CPD carboxypeptidase D
CREG1 cellular repressor of E1A-stimulated genes 1
CTSA cathepsin A
CTSD cathepsin D
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
ELOVL5 ELOVL fatty acid elongase 5
ENO2 enolase 2 (gamma, neuronal)
F13A1 coagulation factor XIII, A1 polypeptide
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GM2A GM2 ganglioside activator
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HMG20B high mobility group 20B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ISCU iron-sulfur cluster assembly enzyme
KIAA1033 KIAA1033
LAMP1 lysosomal-associated membrane protein 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
MAP2K5 mitogen-activated protein kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MERTK MER proto-oncogene, tyrosine kinase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSMO1 methylsterol monooxygenase 1
NDFIP1 Nedd4 family interacting protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAIP1 poly(A) binding protein interacting protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA1A phospholipase A1 member A
PLD3 phospholipase D family, member 3
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF11 ring finger protein 11
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STXBP1 syntaxin binding protein 1
TAC1 tachykinin, precursor 1
TKT transketolase
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHSG alpha-2-HS-glycoprotein
ALB albumin
APOA2 apolipoprotein A-II
BOP1 block of proliferation 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL4A1 collagen, type IV, alpha 1
COL6A1 collagen, type VI, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHFR dihydrofolate reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
EIF4A1 eukaryotic translation initiation factor 4A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ITPKB inositol-trisphosphate 3-kinase B
KIAA0101 KIAA0101
LOC100505650 uncharacterized LOC100505650
LPXN leupaxin
LTF lactotransferrin
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MPO myeloperoxidase
MSH2 mutS homolog 2
MT1M metallothionein 1M
MYRF myelin regulatory factor
NDRG2 NDRG family member 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLAUR plasminogen activator, urokinase receptor
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPIF peptidylprolyl isomerase F
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF6 serine/arginine-rich splicing factor 6
TCP1 t-complex 1
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TNC tenascin C
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VCAN versican
ZWINT ZW10 interacting kinetochore protein
Funding