BRD-K36740062_GSK-1070916_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K36740062_GSK-1070916_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
AHCYL1 adenosylhomocysteinase-like 1
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASMTL acetylserotonin O-methyltransferase-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLNS1A chloride channel, nucleotide-sensitive, 1A
COL4A5 collagen, type IV, alpha 5
CTSL cathepsin L
CUX1 cut-like homeobox 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
ENAH enabled homolog (Drosophila)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCLC glutamate-cysteine ligase, catalytic subunit
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8H golgin A8 family, member H
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLC1 kinesin light chain 1
LAMP5 lysosomal-associated membrane protein family, member 5
LIMCH1 LIM and calponin homology domains 1
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYO6 myosin VI
NAP1L1 nucleosome assembly protein 1-like 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB4 phospholipase C, beta 4
PPARD peroxisome proliferator-activated receptor delta
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RYBP RING1 and YY1 binding protein
SCPEP1 serine carboxypeptidase 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON2 spondin 2, extracellular matrix protein
SQSTM1 sequestosome 1
STK39 serine threonine kinase 39
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM33 tripartite motif containing 33
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
ANGPT2 angiopoietin 2
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD14 CD14 molecule
CD1E CD1e molecule
CD24 CD24 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ELP5 elongator acetyltransferase complex subunit 5
EREG epiregulin
EXOSC4 exosome component 4
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FANCG Fanconi anemia, complementation group G
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GIMAP6 GTPase, IMAP family member 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
HELLS helicase, lymphoid-specific
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI30 interferon, gamma-inducible protein 30
IFRD2 interferon-related developmental regulator 2
KIAA0101 KIAA0101
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LMO4 LIM domain only 4
LUM lumican
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MEF2C myocyte enhancer factor 2C
MPC2 mitochondrial pyruvate carrier 2
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
MTERF3 mitochondrial transcription termination factor 3
MYBPC1 myosin binding protein C, slow type
NPTX2 neuronal pentraxin II
OIP5 Opa interacting protein 5
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLEK2 pleckstrin 2
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTPRC protein tyrosine phosphatase, receptor type, C
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RHOBTB3 Rho-related BTB domain containing 3
RNASE6 ribonuclease, RNase A family, k6
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEPW1 selenoprotein W, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLN sarcolipin
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
STRA13 stimulated by retinoic acid 13
TFRC transferrin receptor
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WSB2 WD repeat and SOCS box containing 2
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein
Funding