BRD-K36740062_GSK-1070916_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K36740062_GSK-1070916_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
APOD apolipoprotein D
AREG amphiregulin
BEX1 brain expressed, X-linked 1
CAST calpastatin
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
CRELD2 cysteine-rich with EGF-like domains 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GMPR guanosine monophosphate reductase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
IRS1 insulin receptor substrate 1
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LMNA lamin A/C
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MVP major vault protein
NAV2 neuron navigator 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PPOX protoporphyrinogen oxidase
PRKCQ protein kinase C, theta
QPCT glutaminyl-peptide cyclotransferase
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100A14 S100 calcium binding protein A14
SAMD4A sterile alpha motif domain containing 4A
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TCEAL4 transcription elongation factor A (SII)-like 4
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNT1 troponin T type 1 (skeletal, slow)
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
VDAC1 voltage-dependent anion channel 1
WASF3 WAS protein family, member 3
WDR45 WD repeat domain 45
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
C8ORF4 chromosome 8 open reading frame 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CKB creatine kinase, brain
EFHD1 EF-hand domain family, member D1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PELI1 pellino E3 ubiquitin protein ligase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PLK1 polo-like kinase 1
PROM1 prominin 1
PTMA prothymosin, alpha
RAB5C RAB5C, member RAS oncogene family
RFC5 replication factor C (activator 1) 5, 36.5kDa
SPP1 secreted phosphoprotein 1
SRSF7 serine/arginine-rich splicing factor 7
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
Funding