BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BGN biglycan
C4BPA complement component 4 binding protein, alpha
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CREB1 cAMP responsive element binding protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ELOVL5 ELOVL fatty acid elongase 5
FABP4 fatty acid binding protein 4, adipocyte
FAR2 fatty acyl CoA reductase 2
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRB10 growth factor receptor-bound protein 10
GSAP gamma-secretase activating protein
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HRH1 histamine receptor H1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
LAMB3 laminin, beta 3
LAMP3 lysosomal-associated membrane protein 3
LGALS8 lectin, galactoside-binding, soluble, 8
LPL lipoprotein lipase
LTF lactotransferrin
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP10 matrix metallopeptidase 10
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOV nephroblastoma overexpressed
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAB20 RAB20, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH2B3 SH2B adaptor protein 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRSF11 serine/arginine-rich splicing factor 11
STK38L serine/threonine kinase 38 like
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TES testin LIM domain protein
TNS1 tensin 1
TRBC1 T cell receptor beta constant 1
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WLS wntless Wnt ligand secretion mediator
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
CALR calreticulin
CD200 CD200 molecule
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTB clathrin, light chain B
COG7 component of oligomeric golgi complex 7
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYBA cytochrome b-245, alpha polypeptide
DLK1 delta-like 1 homolog (Drosophila)
E2F2 E2F transcription factor 2
FAM20B family with sequence similarity 20, member B
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FRZB frizzled-related protein
GSN gelsolin
HMGB3 high mobility group box 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
ISYNA1 inositol-3-phosphate synthase 1
KANK1 KN motif and ankyrin repeat domains 1
LEFTY1 left-right determination factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LXN latexin
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
NOX1 NADPH oxidase 1
NTS neurotensin
OLFML3 olfactomedin-like 3
PDGFD platelet derived growth factor D
PGAM1 phosphoglycerate mutase 1 (brain)
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PROM1 prominin 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOF ras homolog family member F (in filopodia)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC12A8 solute carrier family 12, member 8
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
TFF1 trefoil factor 1
TPD52L1 tumor protein D52-like 1
VCAN versican
ZNF586 zinc finger protein 586
Funding