BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

48 genes differentially expressed following the BRD-K36772364_8-{[2-oxo-2-(1-pyrrolidinyl)ethyl]thio}quinoline_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1QB complement component 1, q subcomponent, B chain
CBR3 carbonyl reductase 3
CSRP1 cysteine and glycine-rich protein 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGFR3 fibroblast growth factor receptor 3
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
INSIG1 insulin induced gene 1
LRRC15 leucine rich repeat containing 15
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMO1 methylsterol monooxygenase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
PLIN2 perilipin 2
PTX3 pentraxin 3, long
PXMP2 peroxisomal membrane protein 2, 22kDa
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULF1 sulfatase 1
THBD thrombomodulin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
APOD apolipoprotein D
B3GNT1
CD44 CD44 molecule (Indian blood group)
CFD complement factor D (adipsin)
CTSH cathepsin H
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
MAOA monoamine oxidase A
PDE8B phosphodiesterase 8B
RNF130 ring finger protein 130
SFRP1 secreted frizzled-related protein 1
SRGN serglycin
VNN1 vanin 1
Funding