BRD-K37206356_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K37206356_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
AUTS2 autism susceptibility candidate 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CFB complement factor B
CXCL2 chemokine (C-X-C motif) ligand 2
DAPK1 death-associated protein kinase 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP6 insulin-like growth factor binding protein 6
IL13RA2 interleukin 13 receptor, alpha 2
KRCC1 lysine-rich coiled-coil 1
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP7 microtubule-associated protein 7
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RNASE4 ribonuclease, RNase A family, 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN1 tetraspanin 1
TXNRD1 thioredoxin reductase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ARG2 arginase 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CFD complement factor D (adipsin)
CNN3 calponin 3, acidic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPT dermatopontin
EMP3 epithelial membrane protein 3
FGFR2 fibroblast growth factor receptor 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSTM3 glutathione S-transferase mu 3 (brain)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
KRT14 keratin 14, type I
LDHB lactate dehydrogenase B
LDLR low density lipoprotein receptor
MAGEA1 melanoma antigen family A1
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MOK MOK protein kinase
MT1X metallothionein 1X
PEG10 paternally expressed 10
PRNP prion protein
S100A6 S100 calcium binding protein A6
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2