BRD-K37687095_AZD-8330_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K37687095_AZD-8330_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CAT catalase
CAV2 caveolin 2
CCNG2 cyclin G2
CD53 CD53 molecule
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
FABP3 fatty acid binding protein 3, muscle and heart
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GPX4 glutathione peroxidase 4
GSN gelsolin
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LOX lysyl oxidase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MGST3 microsomal glutathione S-transferase 3
MT1F metallothionein 1F
MT1X metallothionein 1X
MYL9 myosin, light chain 9, regulatory
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NREP neuronal regeneration related protein
PBLD phenazine biosynthesis-like protein domain containing
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFD platelet derived growth factor D
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PXDN peroxidasin
RAB9A RAB9A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAI2 snail family zinc finger 2
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
SYNPO synaptopodin
TAGLN2 transgelin 2
TFEC transcription factor EC
TPM2 tropomyosin 2 (beta)
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
USP6NL USP6 N-terminal like
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGR2 anterior gradient 2
ARL4C ADP-ribosylation factor-like 4C
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C5 complement component 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCP110 centriolar coiled coil protein 110kDa
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDT1 chromatin licensing and DNA replication factor 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKAP4 cytoskeleton-associated protein 4
COL13A1 collagen, type XIII, alpha 1
COL5A2 collagen, type V, alpha 2
CRISP3 cysteine-rich secretory protein 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEFA4 defensin, alpha 4, corticostatin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV4 ets variant 4
ETV5 ets variant 5
EXO1 exonuclease 1
FAM129A family with sequence similarity 129, member A
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSAP gamma-secretase activating protein
H1F0 H1 histone family, member 0
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
ISL1 ISL LIM homeobox 1
ITGB5 integrin, beta 5
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF18B kinesin family member 18B
KLK11 kallikrein-related peptidase 11
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LTF lactotransferrin
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MSH2 mutS homolog 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEIL3 nei endonuclease VIII-like 3 (E. coli)
PA2G4 proliferation-associated 2G4, 38kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIH1D1 PIH1 domain containing 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCH protein kinase C, eta
PRSS3 protease, serine, 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP1GAP RAP1 GTPase activating protein
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR3 small proline-rich protein 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
TSPAN5 tetraspanin 5
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding