BRD-K37687095_AZD-8330_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K37687095_AZD-8330_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADA adenosine deaminase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BAMBI BMP and activin membrane-bound inhibitor
BPHL biphenyl hydrolase-like (serine hydrolase)
C1QTNF3 C1q and tumor necrosis factor related protein 3
CADM1 cell adhesion molecule 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD58 CD58 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CSRP1 cysteine and glycine-rich protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EPHB2 EPH receptor B2
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GLS glutaminase
GMPR guanosine monophosphate reductase
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HP haptoglobin
IFI27 interferon, alpha-inducible protein 27
IRF9 interferon regulatory factor 9
LCN2 lipocalin 2
LYZ lysozyme
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MFAP5 microfibrillar associated protein 5
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PLN phospholamban
PRDX2 peroxiredoxin 2
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
REEP1 receptor accessory protein 1
REEP5 receptor accessory protein 5
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RHOQ ras homolog family member Q
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
SQLE squalene epoxidase
TFF3 trefoil factor 3 (intestinal)
TP53I3 tumor protein p53 inducible protein 3
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
VLDLR very low density lipoprotein receptor
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EMP1 epithelial membrane protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL1R2 interleukin 1 receptor, type II
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMA3 laminin, alpha 3
LIG1 ligase I, DNA, ATP-dependent
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MYC v-myc avian myelocytomatosis viral oncogene homolog
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG2 non-SMC condensin II complex, subunit G2
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5E 5'-nucleotidase, ecto (CD73)
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSPH phosphoserine phosphatase
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTX3 pentraxin 3, long
RBBP8 retinoblastoma binding protein 8
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNF167 ring finger protein 167
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SIRT3 sirtuin 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAGP small cell adhesion glycoprotein
SMC4 structural maintenance of chromosomes 4
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
YBX1 Y box binding protein 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding