BRD-K37687095_AZD-8330_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K37687095_AZD-8330_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
CALB1 calbindin 1, 28kDa
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
E2F2 E2F transcription factor 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLG filaggrin
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPNMB glycoprotein (transmembrane) nmb
HSPB8 heat shock 22kDa protein 8
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
MFAP5 microfibrillar associated protein 5
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PDZK1 PDZ domain containing 1
PENK proenkephalin
PTGIS prostaglandin I2 (prostacyclin) synthase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
TAGLN transgelin
THBS2 thrombospondin 2
TRH thyrotropin-releasing hormone

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
AREG amphiregulin
BID BH3 interacting domain death agonist
C1ORF116 chromosome 1 open reading frame 116
CA1 carbonic anhydrase I
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDCP1 CUB domain containing protein 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHN1 chimerin 1
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPHA2 EPH receptor A2
EPN2 epsin 2
ETV1 ets variant 1
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HOXA10 homeobox A10
IER3 immediate early response 3
ISG20 interferon stimulated exonuclease gene 20kDa
L1CAM L1 cell adhesion molecule
LAMB3 laminin, beta 3
LIF leukemia inhibitory factor
LTB lymphotoxin beta (TNF superfamily, member 3)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NKX3-1 NK3 homeobox 1
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TCL1A T-cell leukemia/lymphoma 1A
THBD thrombomodulin
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
Funding