BRD-K37764012_PF-3758309_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K37764012_PF-3758309_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DMBT1 deleted in malignant brain tumors 1
E2F2 E2F transcription factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FHL2 four and a half LIM domains 2
GAS6 growth arrest-specific 6
GNAS GNAS complex locus
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
IDS iduronate 2-sulfatase
JUND jun D proto-oncogene
KRT18 keratin 18, type I
KRT8 keratin 8, type II
MSRB2 methionine sulfoxide reductase B2
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NELL2 NEL-like 2 (chicken)
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PEG10 paternally expressed 10
SCAND1 SCAN domain containing 1
SESN1 sestrin 1
SLC22A18 solute carrier family 22, member 18
SOCS2 suppressor of cytokine signaling 2
STK26 serine/threonine protein kinase 26
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TPD52 tumor protein D52

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSCN1 fascin actin-bundling protein 1
FST follistatin
FUS FUS RNA binding protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAL histidine ammonia-lyase
HIST1H4C histone cluster 1, H4c
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KRT10 keratin 10, type I
KRT23 keratin 23, type I
LBR lamin B receptor
LMO4 LIM domain only 4
LPAR1 lysophosphatidic acid receptor 1
LRRC17 leucine rich repeat containing 17
LYPLA1 lysophospholipase I
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NREP neuronal regeneration related protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD23B RAD23 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
RFC2 replication factor C (activator 1) 2, 40kDa
S100A2 S100 calcium binding protein A2
SCGB2A1 secretoglobin, family 2A, member 1
SERBP1 SERPINE1 mRNA binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
VCAN versican
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
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