BRD-K37764012_PF-3758309_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K37764012_PF-3758309_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CCND2 cyclin D2
CES1 carboxylesterase 1
CLU clusterin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPT1A carnitine palmitoyltransferase 1A (liver)
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP1 dual specificity phosphatase 1
EMP2 epithelial membrane protein 2
EPAS1 endothelial PAS domain protein 1
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM5D lysine (K)-specific demethylase 5D
MDM1 Mdm1 nuclear protein homolog (mouse)
MYO6 myosin VI
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
REEP1 receptor accessory protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SORBS1 sorbin and SH3 domain containing 1
SYNM synemin, intermediate filament protein
TOB1 transducer of ERBB2, 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AK4 adenylate kinase 4
ALOX5 arachidonate 5-lipoxygenase
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD200 CD200 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK14 cyclin-dependent kinase 14
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CREB1 cAMP responsive element binding protein 1
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
FABP7 fatty acid binding protein 7, brain
FAM162A family with sequence similarity 162, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FKBP10 FK506 binding protein 10, 65 kDa
FRY furry homolog (Drosophila)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GTPBP8 GTP-binding protein 8 (putative)
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
LAMP5 lysosomal-associated membrane protein family, member 5
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
MCM3 minichromosome maintenance complex component 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MNDA myeloid cell nuclear differentiation antigen
MYO10 myosin X
NREP neuronal regeneration related protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPD7 PAP associated domain containing 7
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PROM1 prominin 1
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RHOBTB3 Rho-related BTB domain containing 3
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
Funding