BRD-K37764012_PF-3758309_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-K37764012_PF-3758309_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABHD2 abhydrolase domain containing 2
ABHD4 abhydrolase domain containing 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ARHGAP6 Rho GTPase activating protein 6
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG3 BCL2-associated athanogene 3
BECN1 beclin 1, autophagy related
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CLCN4 chloride channel, voltage-sensitive 4
COL2A1 collagen, type II, alpha 1
CST3 cystatin C
CTSA cathepsin A
CTSE cathepsin E
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNM1L dynamin 1-like
DRAM1 DNA-damage regulated autophagy modulator 1
EPS8L2 EPS8-like 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FHL1 four and a half LIM domains 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GBP2 guanylate binding protein 2, interferon-inducible
GNS glucosamine (N-acetyl)-6-sulfatase
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
KDM4B lysine (K)-specific demethylase 4B
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LRP10 low density lipoprotein receptor-related protein 10
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OLFM4 olfactomedin 4
OPTN optineurin
PARP12 poly (ADP-ribose) polymerase family, member 12
PDZK1IP1 PDZK1 interacting protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
PVALB parvalbumin
RIOK3 RIO kinase 3
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SGSH N-sulfoglucosamine sulfohydrolase
SIRT3 sirtuin 3
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOM stomatin
STX3 syntaxin 3
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TRIM22 tripartite motif containing 22
TWF2 twinfilin actin binding protein 2
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
C4BPA complement component 4 binding protein, alpha
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNE1 cyclin E1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CFH complement factor H
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CLIC3 chloride intracellular channel 3
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CPB2 carboxypeptidase B2 (plasma)
CST6 cystatin E/M
CTSK cathepsin K
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPCAM epithelial cell adhesion molecule
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GPNMB glycoprotein (transmembrane) nmb
HADH hydroxyacyl-CoA dehydrogenase
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HSPA2 heat shock 70kDa protein 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KLK6 kallikrein-related peptidase 6
LOC100505650 uncharacterized LOC100505650
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MKI67 marker of proliferation Ki-67
MPZL2 myelin protein zero-like 2
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MUC16 mucin 16, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NID2 nidogen 2 (osteonidogen)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RAB20 RAB20, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SEPHS1 selenophosphate synthetase 1
SERINC5 serine incorporator 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
STXBP6 syntaxin binding protein 6 (amisyn)
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPPP3 tubulin polymerization-promoting protein family member 3
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VCAN versican
VRK1 vaccinia related kinase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein
Funding