BRD-K37764012_PF-3758309_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K37764012_PF-3758309_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
ARHGAP29 Rho GTPase activating protein 29
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
CADM1 cell adhesion molecule 1
CAST calpastatin
CAV2 caveolin 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
DPP4 dipeptidyl-peptidase 4
EPHA3 EPH receptor A3
FAM107A family with sequence similarity 107, member A
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
FZD6 frizzled class receptor 6
GCC2 GRIP and coiled-coil domain containing 2
GRN granulin
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIP1R huntingtin interacting protein 1 related
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
MACF1 microtubule-actin crosslinking factor 1
MFAP5 microfibrillar associated protein 5
MT1F metallothionein 1F
MT1M metallothionein 1M
NOTCH2NL notch 2 N-terminal like
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PINK1 PTEN induced putative kinase 1
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RNASET2 ribonuclease T2
TMEM2 transmembrane protein 2
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
VIM vimentin
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOA aldolase A, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CD8A CD8a molecule
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CLC Charcot-Leyden crystal galectin
COL5A2 collagen, type V, alpha 2
CSTA cystatin A (stefin A)
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DKC1 dyskeratosis congenita 1, dyskerin
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP11 FK506 binding protein 11, 19 kDa
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
HMGB2 high mobility group box 2
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LTF lactotransferrin
NKX3-1 NK3 homeobox 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDLIM3 PDZ and LIM domain 3
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLXNC1 plexin C1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PTMA prothymosin, alpha
PYCR1 pyrroline-5-carboxylate reductase 1
RFC3 replication factor C (activator 1) 3, 38kDa
SCGB1D2 secretoglobin, family 1D, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRP72 signal recognition particle 72kDa
SRSF3 serine/arginine-rich splicing factor 3
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS2 thrombospondin 2
TKT transketolase
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRBC1 T cell receptor beta constant 1
TREM1 triggering receptor expressed on myeloid cells 1
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
Funding