BRD-K37764012_PF-3758309_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

264 genes differentially expressed following the BRD-K37764012_PF-3758309_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSF2 acyl-CoA synthetase family member 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD10 ankyrin repeat domain 10
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ASCC3 activating signal cointegrator 1 complex subunit 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD52 CD52 molecule
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERS6 ceramide synthase 6
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP1B charged multivesicular body protein 1B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
FABP4 fatty acid binding protein 4, adipocyte
FAM134A family with sequence similarity 134, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GRN granulin
HCP5 HLA complex P5 (non-protein coding)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HOPX HOP homeobox
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IL32 interleukin 32
IRF8 interferon regulatory factor 8
KIAA0125 KIAA0125
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LTB lymphotoxin beta (TNF superfamily, member 3)
LY75 lymphocyte antigen 75
MALT1 MALT1 paracaspase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MT1G metallothionein 1G
MT1X metallothionein 1X
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLK myosin light chain kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PECAM1 platelet/endothelial cell adhesion molecule 1
POSTN periostin, osteoblast specific factor
PPME1 protein phosphatase methylesterase 1
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
RALGDS ral guanine nucleotide dissociation stimulator
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNF11 ring finger protein 11
RNMT RNA (guanine-7-) methyltransferase
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SIDT2 SID1 transmembrane family, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SMAD3 SMAD family member 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPATA20 spermatogenesis associated 20
SPATA2L spermatogenesis associated 2-like
STOM stomatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSTA3 tissue specific transplantation antigen P35B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCL vinculin
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOC1 apolipoprotein C-I
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKB aurora kinase B
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
C2CD5 C2 calcium-dependent domain containing 5
C7 complement component 7
CALR calreticulin
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPM centromere protein M
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFH complement factor H
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CIT citron rho-interacting serine/threonine kinase
CLEC11A C-type lectin domain family 11, member A
COBL cordon-bleu WH2 repeat protein
DCN decorin
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FBN1 fibrillin 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALE UDP-galactose-4-epimerase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPNMB glycoprotein (transmembrane) nmb
GTF2A2 general transcription factor IIA, 2, 12kDa
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
HAL histidine ammonia-lyase
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
INSIG1 insulin induced gene 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MATN2 matrilin 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MSH2 mutS homolog 2
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE8A phosphodiesterase 8A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PITX1 paired-like homeodomain 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PXDN peroxidasin
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAD51AP1 RAD51 associated protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
RUFY3 RUN and FYVE domain containing 3
RYR1 ryanodine receptor 1 (skeletal)
S100A6 S100 calcium binding protein A6
SCGB2A1 secretoglobin, family 2A, member 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
THBS2 thrombospondin 2
THYN1 thymocyte nuclear protein 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPRKB TP53RK binding protein
TRMT5 tRNA methyltransferase 5
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TUBB tubulin, beta class I
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding