BRD-K37798499_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K37798499_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABLIM1 actin binding LIM protein 1
AEN apoptosis enhancing nuclease
ANKRD10 ankyrin repeat domain 10
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG1 BCL2-associated athanogene
BAX BCL2-associated X protein
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCDC90B coiled-coil domain containing 90B
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CLU clusterin
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
EPHA2 EPH receptor A2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IL1B interleukin 1, beta
IL32 interleukin 32
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIFAP3 kinesin-associated protein 3
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC1 myosin binding protein C, slow type
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAU plasminogen activator, urokinase
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RRAD Ras-related associated with diabetes
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SAMD4A sterile alpha motif domain containing 4A
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC4 syndecan 4
SELE selectin E
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
SUCO SUN domain containing ossification factor
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIGAR TP53 induced glycolysis regulatory phosphatase
TJP2 tight junction protein 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRAF1 TNF receptor-associated factor 1
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CPE carboxypeptidase E
CST1 cystatin SN
CST7 cystatin F (leukocystatin)
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
ECT2 epithelial cell transforming 2
EDNRB endothelin receptor type B
FAM64A family with sequence similarity 64, member A
FGB fibrinogen beta chain
FGF13 fibroblast growth factor 13
FOXG1 forkhead box G1
FOXM1 forkhead box M1
FRZB frizzled-related protein
FZD2 frizzled class receptor 2
GAL galanin/GMAP prepropeptide
GSTA1 glutathione S-transferase alpha 1
GTSE1 G-2 and S-phase expressed 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB3 high mobility group box 3
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSM1 insulinoma-associated 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LBR lamin B receptor
LMNB1 lamin B1
LYZ lysozyme
MAP1B microtubule-associated protein 1B
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
OIP5 Opa interacting protein 5
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE10A phosphodiesterase 10A
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PSCA prostate stem cell antigen
RACGAP1 Rac GTPase activating protein 1
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYND8 zinc finger, MYND-type containing 8