BRD-K38340366_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K38340366_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX1 brain expressed, X-linked 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FTH1 ferritin, heavy polypeptide 1
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
LPL lipoprotein lipase
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPR3 natriuretic peptide receptor 3
PDE4DIP phosphodiesterase 4D interacting protein
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RPL22 ribosomal protein L22
RPS4Y1 ribosomal protein S4, Y-linked 1
RSL1D1 ribosomal L1 domain containing 1
SCG2 secretogranin II
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM50A transmembrane protein 50A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM134B family with sequence similarity 134, member B
FGFBP1 fibroblast growth factor binding protein 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
HES1 hes family bHLH transcription factor 1
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
KIAA0020 KIAA0020
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PRKCD protein kinase C, delta
RAB38 RAB38, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
RPS11 ribosomal protein S11
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFRP1 secreted frizzled-related protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
STAMBP STAM binding protein
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMC6 transmembrane channel-like 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WNT5A wingless-type MMTV integration site family, member 5A
YAP1 Yes-associated protein 1
Funding