BRD-K38615104_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K38615104_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AGR2 anterior gradient 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C3 complement component 3
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CLU clusterin
COL1A2 collagen, type I, alpha 2
CPM carboxypeptidase M
DLK1 delta-like 1 homolog (Drosophila)
DPT dermatopontin
E2F2 E2F transcription factor 2
EGR1 early growth response 1
EGR3 early growth response 3
ESR1 estrogen receptor 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IFITM1 interferon induced transmembrane protein 1
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT8 keratin 8, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
LY6E lymphocyte antigen 6 complex, locus E
MFAP5 microfibrillar associated protein 5
MYH11 myosin, heavy chain 11, smooth muscle
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
PLAGL1 pleiomorphic adenoma gene-like 1
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSAD2 radical S-adenosyl methionine domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SSR4 signal sequence receptor, delta
SST somatostatin
TNS1 tensin 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN1 actinin, alpha 1
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCDC86 coiled-coil domain containing 86
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CEMIP cell migration inducing protein, hyaluronan binding
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MRPS2 mitochondrial ribosomal protein S2
NKX3-1 NK3 homeobox 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PLAC8 placenta-specific 8
PLIN2 perilipin 2
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
PTX3 pentraxin 3, long
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAV1 salvador family WW domain containing protein 1
SCAND1 SCAN domain containing 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SSH1 slingshot protein phosphatase 1
TEX10 testis expressed 10
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPX2 TPX2, microtubule-associated
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
WWTR1 WW domain containing transcription regulator 1
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