BRD-K38615104_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K38615104_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNASE2 deoxyribonuclease II, lysosomal
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KRT4 keratin 4, type II
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NRP1 neuropilin 1
PDE4DIP phosphodiesterase 4D interacting protein
PFKM phosphofructokinase, muscle
PLAU plasminogen activator, urokinase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RTN3 reticulon 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCF4 transcription factor 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS3 transmembrane protease, serine 3
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VIM vimentin

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AHR aryl hydrocarbon receptor
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP76 centrosomal protein 76kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSH cathepsin H
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
ECD ecdysoneless homolog (Drosophila)
EFNA1 ephrin-A1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GEMIN4 gem (nuclear organelle) associated protein 4
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGKV1-5 immunoglobulin kappa variable 1-5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
LSG1 large 60S subunit nuclear export GTPase 1
MALT1 MALT1 paracaspase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MSH6 mutS homolog 6
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PBK PDZ binding kinase
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
RANBP2 RAN binding protein 2
RHOB ras homolog family member B
RIOK2 RIO kinase 2
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RRAGA Ras-related GTP binding A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SETD5 SET domain containing 5
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TBX3 T-box 3
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
TMEM11 transmembrane protein 11
TOB2 transducer of ERBB2, 2
TRAM2 translocation associated membrane protein 2
TUBA4A tubulin, alpha 4a
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VGLL4 vestigial-like family member 4
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
Funding