BRD-K38625260_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K38625260_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ATF5 activating transcription factor 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDB2 damage-specific DNA binding protein 2, 48kDa
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSE1 Gse1 coiled-coil protein
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
MT1E metallothionein 1E
RHOB ras homolog family member B
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
CD24 CD24 molecule
DLK1 delta-like 1 homolog (Drosophila)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYZ lysozyme
MMP7 matrix metallopeptidase 7
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
S100P S100 calcium binding protein P
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
VEGFA vascular endothelial growth factor A