BRD-K39188321_Betamethasone_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K39188321_Betamethasone_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAT1 acetyl-CoA acetyltransferase 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACSL1 acyl-CoA synthetase long-chain family member 1
ADCK3 aarF domain containing kinase 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFF1 AF4/FMR2 family, member 1
AKAP12 A kinase (PRKA) anchor protein 12
ALG8 ALG8, alpha-1,3-glucosyltransferase
AREG amphiregulin
C10ORF10 chromosome 10 open reading frame 10
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD163 CD163 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CLNS1A chloride channel, nucleotide-sensitive, 1A
CPM carboxypeptidase M
CTSE cathepsin E
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNTT DNA nucleotidylexotransferase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F13A1 coagulation factor XIII, A1 polypeptide
FKBP5 FK506 binding protein 5
FPR1 formyl peptide receptor 1
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
LAMC1 laminin, gamma 1 (formerly LAMB2)
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAOA monoamine oxidase A
METRN meteorin, glial cell differentiation regulator
MINA MYC induced nuclear antigen
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SOD2 superoxide dismutase 2, mitochondrial
STK39 serine threonine kinase 39
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TJP2 tight junction protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ALAS1 5'-aminolevulinate synthase 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BAMBI BMP and activin membrane-bound inhibitor
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DCX doublecortin
DENND1B DENN/MADD domain containing 1B
DIO2 deiodinase, iodothyronine, type II
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DOK5 docking protein 5
DSG1 desmoglein 1
DUSP4 dual specificity phosphatase 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR2 early growth response 2
EPHB2 EPH receptor B2
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FHL2 four and a half LIM domains 2
FRZB frizzled-related protein
FZD2 frizzled class receptor 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT1 keratin 1, type II
KRT23 keratin 23, type I
LBH limb bud and heart development
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LIMS1 LIM and senescent cell antigen-like domains 1
MATN2 matrilin 2
MEG3 maternally expressed 3 (non-protein coding)
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCALD neurocalcin delta
NDC80 NDC80 kinetochore complex component
NPAS2 neuronal PAS domain protein 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPHN1 oligophrenin 1
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEK pleckstrin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAD51AP1 RAD51 associated protein 1
RBP1 retinol binding protein 1, cellular
REEP1 receptor accessory protein 1
RELN reelin
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
RRM2 ribonucleotide reductase M2
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOSTDC1 sclerostin domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TUBA4A tubulin, alpha 4a
TUBB2B tubulin, beta 2B class IIb
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
Funding