BRD-K39345836_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K39345836_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ATF3 activating transcription factor 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECM1 extracellular matrix protein 1
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
LOXL2 lysyl oxidase-like 2
MMP11 matrix metallopeptidase 11
MT1X metallothionein 1X
MUC4 mucin 4, cell surface associated
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PKP1 plakophilin 1
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLURP1 secreted LY6/PLAUR domain containing 1
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
CCND1 cyclin D1
DMD dystrophin
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FILIP1L filamin A interacting protein 1-like
GNAS GNAS complex locus
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
PLN phospholamban
RGS5 regulator of G-protein signaling 5
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPAN8 tetraspanin 8
Funding