BRD-K40175214_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K40175214_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
APOD apolipoprotein D
ARID4B AT rich interactive domain 4B (RBP1-like)
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD5 C2 calcium-dependent domain containing 5
CAPN3 calpain 3, (p94)
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
CTSA cathepsin A
DDIT4 DNA-damage-inducible transcript 4
ECT2 epithelial cell transforming 2
EFNA1 ephrin-A1
EIF4A2 eukaryotic translation initiation factor 4A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FMO5 flavin containing monooxygenase 5
FXR1 fragile X mental retardation, autosomal homolog 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB7 homeobox B7
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
ITGB4 integrin, beta 4
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MGLL monoglyceride lipase
MLPH melanophilin
MSX1 msh homeobox 1
MVP major vault protein
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RNF167 ring finger protein 167
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC44A4 solute carrier family 44, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STX1A syntaxin 1A (brain)
TBL1X transducin (beta)-like 1X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
TXNL4B thioredoxin-like 4B
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
B3GNT1
C1ORF116 chromosome 1 open reading frame 116
CCDC85B coiled-coil domain containing 85B
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DICER1 dicer 1, ribonuclease type III
DLC1 DLC1 Rho GTPase activating protein
DUOX2 dual oxidase 2
DUSP14 dual specificity phosphatase 14
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
KRT13 keratin 13, type I
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MSH6 mutS homolog 6
NELL2 NEL-like 2 (chicken)
NKX3-1 NK3 homeobox 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PALLD palladin, cytoskeletal associated protein
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKCH protein kinase C, eta
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PRR7 proline rich 7 (synaptic)
RANBP1 RAN binding protein 1
REG3A regenerating islet-derived 3 alpha
RFC3 replication factor C (activator 1) 3, 38kDa
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOBP sine oculis binding protein homolog (Drosophila)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
SULF1 sulfatase 1
TFAM transcription factor A, mitochondrial
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM109 transmembrane protein 109
TMEM47 transmembrane protein 47
Funding