BRD-K40175214_torin-1_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-K40175214_torin-1_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHNAK2 AHNAK nucleoprotein 2
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANK2 ankyrin 2, neuronal
ANKRD36B ankyrin repeat domain 36B
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATM ATM serine/threonine kinase
BACE2 beta-site APP-cleaving enzyme 2
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANX calnexin
CAPN3 calpain 3, (p94)
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL8 chemokine (C-C motif) ligand 8
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CEP57 centrosomal protein 57kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
COL14A1 collagen, type XIV, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
DPP4 dipeptidyl-peptidase 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHC1 EF-hand domain (C-terminal) containing 1
EIF2D eukaryotic translation initiation factor 2D
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FMOD fibromodulin
FN1 fibronectin 1
FNTA farnesyltransferase, CAAX box, alpha
GATAD1 GATA zinc finger domain containing 1
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSPT2 G1 to S phase transition 2
GUSBP3 glucuronidase, beta pseudogene 3
HDAC9 histone deacetylase 9
HEBP1 heme binding protein 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HEXA hexosaminidase A (alpha polypeptide)
HIST1H2AC histone cluster 1, H2ac
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IRS2 insulin receptor substrate 2
KARS lysyl-tRNA synthetase
KLHL21 kelch-like family member 21
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LRPPRC leucine-rich pentatricopeptide repeat containing
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K5 mitogen-activated protein kinase kinase 5
MLPH melanophilin
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OARD1 O-acyl-ADP-ribose deacylase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARP6 poly (ADP-ribose) polymerase family, member 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PGAP3 post-GPI attachment to proteins 3
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRO protein tyrosine phosphatase, receptor type, O
PYGB phosphorylase, glycogen; brain
RAB29 RAB29, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A38 solute carrier family 25, member 38
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCEAL4 transcription elongation factor A (SII)-like 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM63A transmembrane protein 63A
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TTC37 tetratricopeptide repeat domain 37
URI1 URI1, prefoldin-like chaperone
XIST X inactive specific transcript (non-protein coding)
ZFAND1 zinc finger, AN1-type domain 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTB actin, beta
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CCNF cyclin F
CD99 CD99 molecule
CDA cytidine deaminase
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CLU clusterin
CTSZ cathepsin Z
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1 dynamin 1
E2F8 E2F transcription factor 8
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GAS2L1 growth arrest-specific 2 like 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HJURP Holliday junction recognition protein
HMGB3 high mobility group box 3
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
KIAA0232 KIAA0232
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LAPTM5 lysosomal protein transmembrane 5
LBR lamin B receptor
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRB2 methionine sulfoxide reductase B2
MTERF3 mitochondrial transcription termination factor 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NES nestin
NPTX2 neuronal pentraxin II
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX1 peroxiredoxin 1
PSRC1 proline/serine-rich coiled-coil 1
PXDN peroxidasin
RAD54B RAD54 homolog B (S. cerevisiae)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN1 sestrin 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNN stannin
SNRK SNF related kinase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TACC1 transforming, acidic coiled-coil containing protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBL1X transducin (beta)-like 1X-linked
TK1 thymidine kinase 1, soluble
TMEM2 transmembrane protein 2
TMPO thymopoietin
TMSB15A thymosin beta 15a
TPX2 TPX2, microtubule-associated
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
Funding