| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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286 genes differentially expressed following the BRD-K40175214_torin-1_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| ABHD4 | abhydrolase domain containing 4 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) |
| ANKRD10 | ankyrin repeat domain 10 |
| ANKRD36B | ankyrin repeat domain 36B |
| ATHL1 | ATH1, acid trehalase-like 1 (yeast) |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding |
| BACE2 | beta-site APP-cleaving enzyme 2 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B |
| BDKRB2 | bradykinin receptor B2 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C1RL | complement component 1, r subcomponent-like |
| C2CD2 | C2 calcium-dependent domain containing 2 |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CAST | calpastatin |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCDC28A | coiled-coil domain containing 28A |
| CCNG2 | cyclin G2 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDK19 | cyclin-dependent kinase 19 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CLEC2B | C-type lectin domain family 2, member B |
| CP | ceruloplasmin (ferroxidase) |
| CPD | carboxypeptidase D |
| CREBL2 | cAMP responsive element binding protein-like 2 |
| CST1 | cystatin SN |
| CTGF | connective tissue growth factor |
| CTSA | cathepsin A |
| CTSB | cathepsin B |
| CYTH1 | cytohesin 1 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DST | dystonin |
| EFNA1 | ephrin-A1 |
| EGFR | epidermal growth factor receptor |
| EIF4B | eukaryotic translation initiation factor 4B |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 |
| FCGBP | Fc fragment of IgG binding protein |
| FOXN3 | forkhead box N3 |
| FOXO4 | forkhead box O4 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GBP2 | guanylate binding protein 2, interferon-inducible |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 |
| GLTSCR2 | glioma tumor suppressor candidate region gene 2 |
| GLUL | glutamate-ammonia ligase |
| GPR137B | G protein-coupled receptor 137B |
| GRAMD1C | GRAM domain containing 1C |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HBP1 | HMG-box transcription factor 1 |
| HECA | headcase homolog (Drosophila) |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HMOX1 | heme oxygenase 1 |
| HOOK2 | hook microtubule-tethering protein 2 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 |
| IDS | iduronate 2-sulfatase |
| IFITM1 | interferon induced transmembrane protein 1 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
| INSR | insulin receptor |
| IRS2 | insulin receptor substrate 2 |
| KLF9 | Kruppel-like factor 9 |
| KLHDC2 | kelch domain containing 2 |
| KLHL21 | kelch-like family member 21 |
| KLHL24 | kelch-like family member 24 |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 |
| LMBRD1 | LMBR1 domain containing 1 |
| LRP10 | low density lipoprotein receptor-related protein 10 |
| LXN | latexin |
| LY75 | lymphocyte antigen 75 |
| MACF1 | microtubule-actin crosslinking factor 1 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MARCH6 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase |
| MEIS1 | Meis homeobox 1 |
| MT1E | metallothionein 1E |
| MT1F | metallothionein 1F |
| MT1G | metallothionein 1G |
| MT1H | metallothionein 1H |
| MT1HL1 | metallothionein 1H-like 1 |
| MT1X | metallothionein 1X |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| MYLIP | myosin regulatory light chain interacting protein |
| MYO6 | myosin VI |
| N4BP2L1 | NEDD4 binding protein 2-like 1 |
| NAV2 | neuron navigator 2 |
| NBR1 | neighbor of BRCA1 gene 1 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| PBX1 | pre-B-cell leukemia homeobox 1 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| PRSS8 | protease, serine, 8 |
| RAB17 | RAB17, member RAS oncogene family |
| RAB31 | RAB31, member RAS oncogene family |
| RALGDS | ral guanine nucleotide dissociation stimulator |
| RB1CC1 | RB1-inducible coiled-coil 1 |
| RBM47 | RNA binding motif protein 47 |
| RNF103 | ring finger protein 103 |
| RNF144A | ring finger protein 144A |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RSRP1 | arginine/serine-rich protein 1 |
| RTN2 | reticulon 2 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SATB1 | SATB homeobox 1 |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERINC3 | serine incorporator 3 |
| SFRP4 | secreted frizzled-related protein 4 |
| SH3YL1 | SH3 and SYLF domain containing 1 |
| SLC35E2B | solute carrier family 35, member E2B |
| SLC38A1 | solute carrier family 38, member 1 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing |
| SOS2 | son of sevenless homolog 2 (Drosophila) |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPATA20 | spermatogenesis associated 20 |
| SQSTM1 | sequestosome 1 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TMEM59 | transmembrane protein 59 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TNS3 | tensin 3 |
| TPP1 | tripeptidyl peptidase I |
| TRAPPC6A | trafficking protein particle complex 6A |
| TSC22D3 | TSC22 domain family, member 3 |
| VAT1 | vesicle amine transport 1 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) |
| WDTC1 | WD and tetratricopeptide repeats 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| Symbol | Name |
|---|---|
| ACAT2 | acetyl-CoA acetyltransferase 2 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
| ADGRG2 | adhesion G protein-coupled receptor G2 |
| AK1 | adenylate kinase 1 |
| AK4 | adenylate kinase 4 |
| ALOX15B | arachidonate 15-lipoxygenase, type B |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| ASF1B | anti-silencing function 1B histone chaperone |
| BAG2 | BCL2-associated athanogene 2 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| CA2 | carbonic anhydrase II |
| CALML3 | calmodulin-like 3 |
| CD36 | CD36 molecule (thrombospondin receptor) |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDK4 | cyclin-dependent kinase 4 |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| COL5A1 | collagen, type V, alpha 1 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CTPS1 | CTP synthase 1 |
| CYCS | cytochrome c, somatic |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| EBP | emopamil binding protein (sterol isomerase) |
| ENO1 | enolase 1, (alpha) |
| EXO1 | exonuclease 1 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| FAM57A | family with sequence similarity 57, member A |
| FASN | fatty acid synthase |
| FEN1 | flap structure-specific endonuclease 1 |
| FHL1 | four and a half LIM domains 1 |
| G0S2 | G0/G1 switch 2 |
| GAL | galanin/GMAP prepropeptide |
| GGCT | gamma-glutamylcyclotransferase |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GPI | glucose-6-phosphate isomerase |
| GSTM3 | glutathione S-transferase mu 3 (brain) |
| HBEGF | heparin-binding EGF-like growth factor |
| HCAR3 | hydroxycarboxylic acid receptor 3 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A |
| HN1 | hematological and neurological expressed 1 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 |
| HSPA8 | heat shock 70kDa protein 8 |
| IL1RN | interleukin 1 receptor antagonist |
| KLF4 | Kruppel-like factor 4 (gut) |
| KRT14 | keratin 14, type I |
| KRT16 | keratin 16, type I |
| KRT17 | keratin 17, type I |
| KRT6A | keratin 6A, type II |
| KRT6B | keratin 6B, type II |
| LAGE3 | L antigen family, member 3 |
| LRRC59 | leucine rich repeat containing 59 |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| MALL | mal, T-cell differentiation protein-like |
| MCAM | melanoma cell adhesion molecule |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| MINA | MYC induced nuclear antigen |
| MRPL12 | mitochondrial ribosomal protein L12 |
| MTCH2 | mitochondrial carrier 2 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PCCB | propionyl CoA carboxylase, beta polypeptide |
| PCNA | proliferating cell nuclear antigen |
| PFN2 | profilin 2 |
| PGK1 | phosphoglycerate kinase 1 |
| PGM1 | phosphoglucomutase 1 |
| PLBD1 | phospholipase B domain containing 1 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| PNP | purine nucleoside phosphorylase |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit |
| PPARG | peroxisome proliferator-activated receptor gamma |
| PPIF | peptidylprolyl isomerase F |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 |
| PTRF | polymerase I and transcript release factor |
| RAD51 | RAD51 recombinase |
| RAN | RAN, member RAS oncogene family |
| RANBP1 | RAN binding protein 1 |
| RFC2 | replication factor C (activator 1) 2, 40kDa |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| S100A2 | S100 calcium binding protein A2 |
| S100A6 | S100 calcium binding protein A6 |
| S100A7 | S100 calcium binding protein A7 |
| S100A8 | S100 calcium binding protein A8 |
| S100A9 | S100 calcium binding protein A9 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| SFN | stratifin |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLPI | secretory leukocyte peptidase inhibitor |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa |
| SNX10 | sorting nexin 10 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 |
| SPRR1A | small proline-rich protein 1A |
| SPRR1B | small proline-rich protein 1B |
| SPRR3 | small proline-rich protein 3 |
| SQLE | squalene epoxidase |
| SRM | spermidine synthase |
| TCL1A | T-cell leukemia/lymphoma 1A |
| TIPIN | TIMELESS interacting protein |
| TK1 | thymidine kinase 1, soluble |
| TMEM47 | transmembrane protein 47 |
| TMPO | thymopoietin |
| TP53 | tumor protein p53 |
| TPM1 | tropomyosin 1 (alpha) |
| TPSAB1 | tryptase alpha/beta 1 |
| TPSB2 | tryptase beta 2 (gene/pseudogene) |
| TRIB3 | tribbles pseudokinase 3 |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TUBB | tubulin, beta class I |
| TUBB2A | tubulin, beta 2A class IIa |
| TUBB3 | tubulin, beta 3 class III |
| TUBB4B | tubulin, beta 4B class IVb |
| TUBB6 | tubulin, beta 6 class V |
| TUBG1 | tubulin, gamma 1 |
| TYMS | thymidylate synthetase |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 |
| USP1 | ubiquitin specific peptidase 1 |
| VBP1 | von Hippel-Lindau binding protein 1 |
| VRK1 | vaccinia related kinase 1 |
| ZWINT | ZW10 interacting kinetochore protein |
