BRD-K40175214_torin-1_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K40175214_torin-1_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOQ adiponectin, C1Q and collagen domain containing
AEBP1 AE binding protein 1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ARMCX1 armadillo repeat containing, X-linked 1
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COCH cochlin
CTSK cathepsin K
CYTH1 cytohesin 1
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
FAM189A2 family with sequence similarity 189, member A2
FOXN3 forkhead box N3
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HDAC9 histone deacetylase 9
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LAMA4 laminin, alpha 4
LETMD1 LETM1 domain containing 1
LIMS1 LIM and senescent cell antigen-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
MMP2 matrix metallopeptidase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPDC1 neural proliferation, differentiation and control, 1
NUP210 nucleoporin 210kDa
PAWR PRKC, apoptosis, WT1, regulator
PDLIM5 PDZ and LIM domain 5
PGLS 6-phosphogluconolactonase
PHC1 polyhomeotic homolog 1 (Drosophila)
PHYH phytanoyl-CoA 2-hydroxylase
POSTN periostin, osteoblast specific factor
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTEN phosphatase and tensin homolog
PTPRO protein tyrosine phosphatase, receptor type, O
PXDN peroxidasin
RGS5 regulator of G-protein signaling 5
RPL15 ribosomal protein L15
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
S100A7 S100 calcium binding protein A7
SET SET nuclear proto-oncogene
SFN stratifin
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRIP6 thyroid hormone receptor interactor 6
TWIST1 twist family bHLH transcription factor 1
VAT1 vesicle amine transport 1
VCAN versican
XYLT1 xylosyltransferase I
YBX3 Y box binding protein 3
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ADGRG1 adhesion G protein-coupled receptor G1
ADI1 acireductone dioxygenase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA6 annexin A6
ARF4 ADP-ribosylation factor 4
ASS1 argininosuccinate synthase 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNB1 cyclin B1
CCND2 cyclin D2
CD58 CD58 molecule
CDC20 cell division cycle 20
CFB complement factor B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CTSC cathepsin C
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EGR1 early growth response 1
EMP3 epithelial membrane protein 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC59 leucine rich repeat containing 59
MAGED1 melanoma antigen family D1
MAL mal, T-cell differentiation protein
MAP1A microtubule-associated protein 1A
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NEFH neurofilament, heavy polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NSF N-ethylmaleimide-sensitive factor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PDZK1 PDZ domain containing 1
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RRBP1 ribosome binding protein 1
S100A4 S100 calcium binding protein A4
SCARB1 scavenger receptor class B, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUB1 SUB1 homolog (S. cerevisiae)
TMED9 transmembrane emp24 protein transport domain containing 9
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UXS1 UDP-glucuronate decarboxylase 1
WT1 Wilms tumor 1
ZBTB18 zinc finger and BTB domain containing 18
Funding