BRD-K40175214_torin-1_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AHNAK2 AHNAK nucleoprotein 2
ANXA4 annexin A4
AREG amphiregulin
ARG1 arginase 1
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND1 cyclin D1
CDK19 cyclin-dependent kinase 19
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
COL6A1 collagen, type VI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRABP1 cellular retinoic acid binding protein 1
DEFB1 defensin, beta 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
EPAS1 endothelial PAS domain protein 1
F2R coagulation factor II (thrombin) receptor
FNBP1 formin binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXD1 forkhead box D1
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HDAC9 histone deacetylase 9
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGBP1 immunoglobulin (CD79A) binding protein 1
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUP junction plakoglobin
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT1 keratin 1, type II
KRT2 keratin 2, type II
LAMC2 laminin, gamma 2
LOR loricrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MFGE8 milk fat globule-EGF factor 8 protein
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPTN optineurin
PERP PERP, TP53 apoptosis effector
PILRB paired immunoglobin-like type 2 receptor beta
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
RPL36 ribosomal protein L36
RRAGD Ras-related GTP binding D
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A1 solute carrier family 38, member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SSH3 slingshot protein phosphatase 3
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
SVIL supervillin
TRAK2 trafficking protein, kinesin binding 2
TSC22D1 TSC22 domain family, member 1
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA2 annexin A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C20ORF24 chromosome 20 open reading frame 24
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CFI complement factor I
CLIC3 chloride intracellular channel 3
CLU clusterin
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECM1 extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GSTT1 glutathione S-transferase theta 1
HAT1 histone acetyltransferase 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MB myoglobin
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHCBP1 SHC SH2-domain binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SRGN serglycin
TFRC transferrin receptor
TIMELESS timeless circadian clock
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM14A transmembrane protein 14A
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
YARS tyrosyl-tRNA synthetase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein
Funding