| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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249 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
| ADIRF | adipogenesis regulatory factor |
| AHNAK2 | AHNAK nucleoprotein 2 |
| AMDHD2 | amidohydrolase domain containing 2 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 |
| ANGPTL2 | angiopoietin-like 2 |
| ANKRD10 | ankyrin repeat domain 10 |
| ANKRD36B | ankyrin repeat domain 36B |
| ANXA4 | annexin A4 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
| CAMLG | calcium modulating ligand |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
| CCND1 | cyclin D1 |
| CHN1 | chimerin 1 |
| CHN2 | chimerin 2 |
| CIRBP | cold inducible RNA binding protein |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
| COL10A1 | collagen, type X, alpha 1 |
| COL6A1 | collagen, type VI, alpha 1 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
| CREB1 | cAMP responsive element binding protein 1 |
| DEFB1 | defensin, beta 1 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 |
| DOK5 | docking protein 5 |
| DSP | desmoplakin |
| EFNB2 | ephrin-B2 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D |
| EIF4A1 | eukaryotic translation initiation factor 4A1 |
| ETHE1 | ethylmalonic encephalopathy 1 |
| F13A1 | coagulation factor XIII, A1 polypeptide |
| F2R | coagulation factor II (thrombin) receptor |
| FN1 | fibronectin 1 |
| FNBP1 | formin binding protein 1 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| GADD45B | growth arrest and DNA-damage-inducible, beta |
| GPNMB | glycoprotein (transmembrane) nmb |
| GSE1 | Gse1 coiled-coil protein |
| HIST3H2A | histone cluster 3, H2a |
| HMGA2 | high mobility group AT-hook 2 |
| HOXD1 | homeobox D1 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IRS1 | insulin receptor substrate 1 |
| IRS2 | insulin receptor substrate 2 |
| JAG1 | jagged 1 |
| KIAA1033 | KIAA1033 |
| KLF6 | Kruppel-like factor 6 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) |
| KLHL21 | kelch-like family member 21 |
| KLHL24 | kelch-like family member 24 |
| KLK8 | kallikrein-related peptidase 8 |
| LAMC2 | laminin, gamma 2 |
| LETMD1 | LETM1 domain containing 1 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MFAP5 | microfibrillar associated protein 5 |
| MFGE8 | milk fat globule-EGF factor 8 protein |
| MMP11 | matrix metallopeptidase 11 |
| MXRA7 | matrix-remodelling associated 7 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| N4BP2L1 | NEDD4 binding protein 2-like 1 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 |
| NCOA3 | nuclear receptor coactivator 3 |
| NOTCH2NL | notch 2 N-terminal like |
| NPC1 | Niemann-Pick disease, type C1 |
| NPDC1 | neural proliferation, differentiation and control, 1 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase |
| OPTN | optineurin |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| PDE9A | phosphodiesterase 9A |
| PILRB | paired immunoglobin-like type 2 receptor beta |
| PLAT | plasminogen activator, tissue |
| PLAU | plasminogen activator, urokinase |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) |
| PLXNA1 | plexin A1 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PTPRO | protein tyrosine phosphatase, receptor type, O |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein |
| PXDC1 | PX domain containing 1 |
| RAB40B | RAB40B, member RAS oncogene family |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 |
| RGS10 | regulator of G-protein signaling 10 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 |
| RPL10 | ribosomal protein L10 |
| RSRP1 | arginine/serine-rich protein 1 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) |
| SLC35E2B | solute carrier family 35, member E2B |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SPON2 | spondin 2, extracellular matrix protein |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STAB1 | stabilin 1 |
| STX1A | syntaxin 1A (brain) |
| SULF1 | sulfatase 1 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| TMPRSS3 | transmembrane protease, serine 3 |
| TPP1 | tripeptidyl peptidase I |
| TPR | translocated promoter region, nuclear basket protein |
| TRA2A | transformer 2 alpha homolog (Drosophila) |
| TRAK2 | trafficking protein, kinesin binding 2 |
| TRAPPC6A | trafficking protein particle complex 6A |
| TSPAN5 | tetraspanin 5 |
| TTC17 | tetratricopeptide repeat domain 17 |
| TTC3 | tetratricopeptide repeat domain 3 |
| UBE2B | ubiquitin-conjugating enzyme E2B |
| VAT1 | vesicle amine transport 1 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) |
| WDR13 | WD repeat domain 13 |
| XIST | X inactive specific transcript (non-protein coding) |
| ZMIZ1 | zinc finger, MIZ-type containing 1 |
| ZNF264 | zinc finger protein 264 |
| ZNF266 | zinc finger protein 266 |
| ZNF277 | zinc finger protein 277 |
| ZNF292 | zinc finger protein 292 |
| ZNF331 | zinc finger protein 331 |
| ZNF83 | zinc finger protein 83 |
| ZNF91 | zinc finger protein 91 |
| Symbol | Name |
|---|---|
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ASPH | aspartate beta-hydroxylase |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| C20ORF24 | chromosome 20 open reading frame 24 |
| CCL19 | chemokine (C-C motif) ligand 19 |
| CCND3 | cyclin D3 |
| CD320 | CD320 molecule |
| CDC25A | cell division cycle 25A |
| CDC6 | cell division cycle 6 |
| CDC7 | cell division cycle 7 |
| CDK2 | cyclin-dependent kinase 2 |
| CENPU | centromere protein U |
| CFH | complement factor H |
| CKAP4 | cytoskeleton-associated protein 4 |
| CLU | clusterin |
| CTSC | cathepsin C |
| CTSZ | cathepsin Z |
| CYB5A | cytochrome b5 type A (microsomal) |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DHCR24 | 24-dehydrocholesterol reductase |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUOX2 | dual oxidase 2 |
| DUT | deoxyuridine triphosphatase |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| EIF5A | eukaryotic translation initiation factor 5A |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) |
| FBP1 | fructose-1,6-bisphosphatase 1 |
| FEN1 | flap structure-specific endonuclease 1 |
| FKBP14 | FK506 binding protein 14, 22 kDa |
| G6PD | glucose-6-phosphate dehydrogenase |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GSTA1 | glutathione S-transferase alpha 1 |
| GSTM3 | glutathione S-transferase mu 3 (brain) |
| GSTT1 | glutathione S-transferase theta 1 |
| HAT1 | histone acetyltransferase 1 |
| HK2 | hexokinase 2 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HMGN3 | high mobility group nucleosomal binding domain 3 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
| HSPB8 | heat shock 22kDa protein 8 |
| ICMT | isoprenylcysteine carboxyl methyltransferase |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 |
| KIAA0101 | KIAA0101 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 |
| LMNB1 | lamin B1 |
| LRRC59 | leucine rich repeat containing 59 |
| LYZ | lysozyme |
| MARS | methionyl-tRNA synthetase |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM5 | minichromosome maintenance complex component 5 |
| METTL7A | methyltransferase like 7A |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| MSMO1 | methylsterol monooxygenase 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYCBP | MYC binding protein |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| NEFL | neurofilament, light polypeptide |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NSF | N-ethylmaleimide-sensitive factor |
| PARP1 | poly (ADP-ribose) polymerase 1 |
| PCNA | proliferating cell nuclear antigen |
| PDIA3 | protein disulfide isomerase family A, member 3 |
| PDIA4 | protein disulfide isomerase family A, member 4 |
| PEX11A | peroxisomal biogenesis factor 11 alpha |
| PGAM1 | phosphoglycerate mutase 1 (brain) |
| PGC | progastricsin (pepsinogen C) |
| PHGDH | phosphoglycerate dehydrogenase |
| PIR | pirin (iron-binding nuclear protein) |
| PLAC8 | placenta-specific 8 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| PRDX1 | peroxiredoxin 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase |
| RRM2 | ribonucleotide reductase M2 |
| S100A11 | S100 calcium binding protein A11 |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) |
| SELT | selenoprotein T |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 |
| SNAP25 | synaptosomal-associated protein, 25kDa |
| SPP1 | secreted phosphoprotein 1 |
| SQLE | squalene epoxidase |
| TARS | threonyl-tRNA synthetase |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| TECR | trans-2,3-enoyl-CoA reductase |
| TIGAR | TP53 induced glycolysis regulatory phosphatase |
| TIMELESS | timeless circadian clock |
| TIMM17A | translocase of inner mitochondrial membrane 17 homolog A (yeast) |
| TMEM47 | transmembrane protein 47 |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TRIM16 | tripartite motif containing 16 |
| TUBG1 | tubulin, gamma 1 |
| TYMS | thymidylate synthetase |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
| ZWINT | ZW10 interacting kinetochore protein |
