BRD-K40175214_torin-1_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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95 genes differentially expressed following the BRD-K40175214_torin-1_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP7 A kinase (PRKA) anchor protein 7
ANXA2 annexin A2
ARID5B AT rich interactive domain 5B (MRF1-like)
BCL6 B-cell CLL/lymphoma 6
BTN3A2 butyrophilin, subfamily 3, member A2
CALML5 calmodulin-like 5
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CD8A CD8a molecule
CHRDL1 chordin-like 1
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CST3 cystatin C
DSP desmoplakin
F2R coagulation factor II (thrombin) receptor
FABP7 fatty acid binding protein 7, brain
FAM13A family with sequence similarity 13, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
KRT14 keratin 14, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
NKG7 natural killer cell granule protein 7
NMT2 N-myristoyltransferase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
PRF1 perforin 1 (pore forming protein)
PTN pleiotrophin
S100A10 S100 calcium binding protein A10
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STK17A serine/threonine kinase 17a
TM4SF1 transmembrane 4 L six family member 1
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TXNL4B thioredoxin-like 4B

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CTSZ cathepsin Z
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EIF5B eukaryotic translation initiation factor 5B
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
GPRC5A G protein-coupled receptor, class C, group 5, member A
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAT2A methionine adenosyltransferase II, alpha
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
MUC1 mucin 1, cell surface associated
NOLC1 nucleolar and coiled-body phosphoprotein 1
ORC1 origin recognition complex, subunit 1
PCDH9 protocadherin 9
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAP25 synaptosomal-associated protein, 25kDa
SRGN serglycin
SST somatostatin
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TM4SF4 transmembrane 4 L six family member 4
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM47 transmembrane protein 47
TMX4 thioredoxin-related transmembrane protein 4
TUBA4A tubulin, alpha 4a
VAMP8 vesicle-associated membrane protein 8