BRD-K40175214_torin-1_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K40175214_torin-1_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
AMIGO2 adhesion molecule with Ig-like domain 2
ARG1 arginase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATMIN ATM interactor
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPI bactericidal/permeability-increasing protein
BSG basigin (Ok blood group)
C1R complement component 1, r subcomponent
CCL8 chemokine (C-C motif) ligand 8
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLDN10 claudin 10
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSD cathepsin D
DCLK1 doublecortin-like kinase 1
DEFA4 defensin, alpha 4, corticostatin
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP4 dual specificity phosphatase 4
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPN2 epsin 2
ESR1 estrogen receptor 1
EXT1 exostosin glycosyltransferase 1
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF13 fibroblast growth factor 13
FOXG1 forkhead box G1
FXR1 fragile X mental retardation, autosomal homolog 1
GATAD1 GATA zinc finger domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX4 glutathione peroxidase 4
GREB1 growth regulation by estrogen in breast cancer 1
GRN granulin
HBP1 HMG-box transcription factor 1
HP haptoglobin
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMB2 laminin, beta 2 (laminin S)
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100505650 uncharacterized LOC100505650
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTA1 metastasis associated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NINJ2 ninjurin 2
NT5E 5'-nucleotidase, ecto (CD73)
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAWR PRKC, apoptosis, WT1, regulator
PCBP2 poly(rC) binding protein 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLK2 polo-like kinase 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKD1 protein kinase D1
PSD3 pleckstrin and Sec7 domain containing 3
PTEN phosphatase and tensin homolog
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SF3A2 splicing factor 3a, subunit 2, 66kDa
SFRP4 secreted frizzled-related protein 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIB2 tribbles pseudokinase 2
TSC2 tuberous sclerosis 2
ZBTB10 zinc finger and BTB domain containing 10
ZC3H12A zinc finger CCCH-type containing 12A
ZNF277 zinc finger protein 277
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOLD1 apolipoprotein L domain containing 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C14ORF169 chromosome 14 open reading frame 169
CCNA2 cyclin A2
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CSTA cystatin A (stefin A)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GPX2 glutathione peroxidase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXC10 homeobox C10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
OLFM1 olfactomedin 1
OPN3 opsin 3
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RGS1 regulator of G-protein signaling 1
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPL39L ribosomal protein L39-like
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SDC1 syndecan 1
SHCBP1 SHC SH2-domain binding protein 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein
Funding