BRD-K40175214_torin-1_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-K40175214_torin-1_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AMDHD2 amidohydrolase domain containing 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATMIN ATM interactor
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMLG calcium modulating ligand
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
COLEC12 collectin sub-family member 12
CREG1 cellular repressor of E1A-stimulated genes 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
DIAPH2 diaphanous-related formin 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
ENOSF1 enolase superfamily member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
FAM134A family with sequence similarity 134, member A
FBXW4 F-box and WD repeat domain containing 4
FOXN3 forkhead box N3
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATAD1 GATA zinc finger domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA4 golgin A4
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
GPC4 glypican 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX4 glutathione peroxidase 4
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HEATR1 HEAT repeat containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JAG1 jagged 1
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
KRT6A keratin 6A, type II
KTN1 kinectin 1 (kinesin receptor)
LAMA3 laminin, alpha 3
LAMB2 laminin, beta 2 (laminin S)
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MERTK MER proto-oncogene, tyrosine kinase
MID1 midline 1
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDGFD platelet derived growth factor D
PDLIM5 PDZ and LIM domain 5
PILRB paired immunoglobin-like type 2 receptor beta
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPL periplakin
PTEN phosphatase and tensin homolog
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRR1B small proline-rich protein 1B
ST7 suppression of tumorigenicity 7
STK38L serine/threonine kinase 38 like
STON1 stonin 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
URI1 URI1, prefoldin-like chaperone
USP34 ubiquitin specific peptidase 34
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAC WW domain containing adaptor with coiled-coil
WBP2 WW domain binding protein 2
WSB1 WD repeat and SOCS box containing 1
YBX3 Y box binding protein 3
ZBTB16 zinc finger and BTB domain containing 16
ZFP36L2 ZFP36 ring finger protein-like 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK1 adenylate kinase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CLIC4 chloride intracellular channel 4
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
EREG epiregulin
EXO1 exonuclease 1
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HOXC10 homeobox C10
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMO4 LIM domain only 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCAPG2 non-SMC condensin II complex, subunit G2
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP prolactin-induced protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PSPH phosphoserine phosphatase
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SESN1 sestrin 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPC25 SPC25, NDC80 kinetochore complex component
SQLE squalene epoxidase
STC2 stanniocalcin 2
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOX3 TOX high mobility group box family member 3
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
WARS tryptophanyl-tRNA synthetase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein
Funding