BRD-K40175214_torin-1_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K40175214_torin-1_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ASPH aspartate beta-hydroxylase
BHLHE40 basic helix-loop-helix family, member e40
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDN3 endothelin 3
ETV1 ets variant 1
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GNLY granulysin
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HP haptoglobin
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IL1R1 interleukin 1 receptor, type I
IPO13 importin 13
KCTD12 potassium channel tetramerization domain containing 12
KLK6 kallikrein-related peptidase 6
KLK8 kallikrein-related peptidase 8
KRT6A keratin 6A, type II
LDLR low density lipoprotein receptor
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPC1 Niemann-Pick disease, type C1
PSAP prosaposin
RB1CC1 RB1-inducible coiled-coil 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
VCAN versican
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
APOO apolipoprotein O
ASS1 argininosuccinate synthase 1
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CDC25A cell division cycle 25A
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CREB1 cAMP responsive element binding protein 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GAL galanin/GMAP prepropeptide
HOXC10 homeobox C10
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAP7 microtubule-associated protein 7
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDPN podoplanin
PRDX4 peroxiredoxin 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SESN1 sestrin 1
SIRT3 sirtuin 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TMEM176B transmembrane protein 176B
TUBB2A tubulin, beta 2A class IIa
VAMP8 vesicle-associated membrane protein 8
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding